The role of cardiovascular diseases in the development of Alzheimer’s disease and cognitive impairment, including COVID-19

Evdokimova A. G., Stryuk R. I., Evdokimov V. V., Kiparisova E. S.

ABSTRACT

Alzheimer’s disease (AD) is a complex neurological disease with a long latency period, which belongs to the group of neurodegenerative diseases. It is the most common neurogeriatric pathology that is characterized by the accumulation of beta-amyloid protein in the form of amyloid plaques and Tau protein (pTau) forming neurofibrillary glomeruli (NFG) in the neuronal bodies due to genetic factors. However, cardiovascular diseases (CVD), including arterial hypertension (AH), has been found to be a significant risk factor. Early manifestations of AD  include cognitive impairment (CI), which in real clinical practice is first encountered by primary care physicians: general practitioners, internists, cardiologists, neurologists. In addition, due to the COVID pandemic the number of patients with AD  has significantly increased. CI  is the most frequent neurological complication in the post-covid period, therefore, its timely diagnosis and correction will allow to slow down the progression of AD.

Key words: Alzheimer’s disease, cognitive impairment, arterial hypertension, COVID-19, cholinesterase inhibitors, neuroprotective therapy.

For citation:

Evdokimova A.G., Stryuk R.I., Evdokimov V.V., Kiparisova E.S.  The role of cardiovascular diseases in the development of Alzheimer’s disease and cognitive impairment, including COVID-19. International Journal of Heart and Vascular Diseases. 2023. 38(11):4-15. DOI: 10.24412/2311-1623-2023-38-5-17